Alchemy: the mystical power to alter the natural world; something between magic, art and science. When two brothers, Edward and Alphonse Elric, dabbled in this power to grant their dearest wish, one of them lost an arm and a leg...and the other became nothing but a soul locked into a body of living steel. Now Edward is an agent of the government, a slave of the military-alchemical complex, using his unique powers to obey orders...even to kill.

Except his powers aren't unique. The world has been ravaged by the abuse of alchemy. And in pursuit of the ultimate alchemical treasure, the Philosopher's Stone, their enemies are even more ruthless than they are...

Ed, Al and Winry return to Central Command, but only bad news greets the Fullmetal Alchemist and his friends. Lieutenant Colonel Maes Hughes has been murdered--and Second Lieutenant Maria Ross is the prime suspect! While Maria awaits an uncertain fate in jail, the living suit of armor bearing the soul of serial killer "Barry the Chopper" breaks free of the military and goes on a rampage. Now, the mysterious Homunculi must come out of the shadows to deal with the mess before their monstrous conspiracy is exposed. But for Colonel Mustang, Maes Hughes's former best friend, it's not about the truth; it's about revenge...